Lead Discovery Scientist (m/w/d) (temporary position for 2 years)

Octapharma Biopharmaceuticals GmbH a subsidiary of the Octapharma group founded in 1997 is a successful and expanding biotech company in Heidelberg. Our core business is the development of recombinant proteins produced in human cell lines for therapeutic use in humans.

We are looking for

a skilled Scientist (m/w/d) to join Octapharma’s Lead Discovery team in Heidelberg focusing on screening antibody libraries and identifying lead candidate molecules as therapeutics in the field of Immunology and Haematology. The scientist will work in a collaborative multi-disciplinary team where she/he plans and executes experiments related to lead discovery and antibody characterization.

The position is available at the next possible date at our site in Heidelberg, Germany and is limited to 2 years with possible extension.

Role and Responsibilities:

  • Develop, implement and continuously re-evaluate high-throughput, cutting-edge screening strategies for antibodies, antibody fragments and other affinity reagents
  • Construct antibody libraries and perform antibody fragment display experiments, contribute to lead identification, functional characterization (e.g. via SPR or BLI) and optimization (e.g. humanization and affinity maturation)
  • Engineer and reformat antibodies using structure-guided approaches and other emerging technologies
  • Independently design and conduct complex experiments, analyze data, document and interpret results and modify strategies as needed
  • Keep up with the latest developments in the field and integrate the information in the
  • Work collaboratively in cross functional teams with other scientists on timeline-driven projects

Qualifications and Education Requirements:

  • Degree in the life sciences (biochemistry, molecular biology, protein engineering, immunology or similar) with applicable experience in academia or industry:
    • Bachelor degree with more than 6 years of relevant experience
    • Master degree with more than 4 years of relevant experience
    • PhD with 0-5 years of relevant experience
  • Hands-on expertise in antibody engineering and antibody fragment display techniques (phage, yeast or other)
  • Experience in analyzing protein-protein interactions using SPR or BLI as well as in standard biophysical protein analysis methods (e.g. Western Blot, SDS PAGE, SEC)
  • Hands-on expertise in computational analysis of antibody sequences or structures
  • Ability to independently conceive experiments, develop assays, optimize protocols and interpret experimental results
  • Desire to learn new techniques and implement them
  • Strong organization and outstanding problem-solving skills, critical and independent thinking, ability to multi-task and attention to detail
  • Active participation and communication in cross-functional project teams

Additional, valued qualifications:

  • Knowledge about cutting-edge biologics formats such as multi-specific antibodies, antibody fragments and other affinity reagents
  • Expertise in using automation platforms for high-throughput screening
  • Experience with NGS antibody sequence analysis
  • Expertise in protein expression and purification

What we have to offer:

  • Become a member of a multi-disciplinary team of scientists
  • Work in a welcoming and scientifically inspiring atmosphere
  • Have a wide range of tasks in a cooperative setting, flexibility and personal responsibility
  • Stay informed about recent trends by attending scientific conferences and workshops
  • Further education, self-improvement and training opportunities
  • Work in modern, state-of-the art equipped labs
  • Flexible working hours
  • A 2-year position in a dynamically growing company

How to apply: please apply via web portal only.

Contact person:
Simone Maciej – Personalreferentin
Tel: (0)6221 –

Key facts about Octapharma Headquartered in Lachen, Switzerland, Octapharma Group is one of the largest human protein products manufacturers in the world and has been committed to patient care and medical innovation for 30 years. Our core business is the development, production and sale of human proteins from human plasma and human cell-lines. Patients in over 100 countries are treated with products in the therapeutic areas Haematology, Immunotherapy and Intensive Care and Emergency Medicine. Octapharma owns five state-of-the-art production facilities in Austria, France, Germany, Sweden and Mexico. For more information visit

Lead Discovery Scientist (m/w/d) Festanstellung Vollzeit Octapharma Biopharmaceuticals GmbH Heidelberg Chemie,Pharma,Weitere: Chemie, Pharma & Medizin Biotechnologie,Medizinische Forschung,Naturwissenschaften,Entwicklung Festanstellung Vollzeit Mit Berufserfahrung Octapharma Biopharmaceuticals GmbH ist ein 1997 gegründetes, erfolgreich expandierendes Biotechnologie-Unternehmen und eines der Tochterunternehmen der Octapharma AG. Unsere Kernkompetenz liegt in der Forschung und Entwicklung von humanen Zelllinien zur Herstellung rekombinanter Arzneimittel.